Neurobiology of Pyridoxine

A case report of pyridoxine dependent seizure

pyridoxine dependent seizure have been recornized as a rare and important cause of intractable seizure in neonates and infants.prompt diagnosis and treatment can stop and prevent these seizure and consequential developmental disabilities.furthermore it can eliminate the unnecessary administration of anticonvulsant medications and thier side effects.the paitient was 7 months old infant who was r...

Pyridoxine responsive epilepsy: expanded pyridoxine dependency?

Pyridoxine-responsive anemia: influence of tryptophan on pyridoxine responsiveness.

This study presents evidence that the indolic amino acid, tryptophan, critically influences pyridoxine responsiveness in a patient with pyridoxine-responsive anemia. Continuing observations for 18 yr on this now 54-yr-old white man have shown responsiveness to oral crude liver extract and to pyridoxine. In addition, remissions of 8-mo duration followed oral administration of fractions of liver ...

Pyridoxine dependent convulsion: effect of pyridoxine therapy on electroencephalograms.

IINUMA, K., NARISAWA, K., YAMAUCHI, N., YOSHIDA, T. and MIZUNO, T. Pyridoxine Dependent Convulsion: Effect of Pyridoxine Therapy on Electro encephalograms. Tohoku J. exp. Med., 1971, 105 (1), 19-26 In a 7-month old boy with vitamin B6 dependent convulsion it was found that distribution of energy % of the EEG basic waves as well as an auto-correlogram of EEG remained abnormal 24 hours after an i...

Studies of pyridoxine displacement.

Relatively little work has been done with pyridoxine displacers. Ott (1) found 2,4-dimethyl-3-hydroxy-5-hydroxymethylpyridoxine (desoxypyridoxine) to be a very potent inhibitor of pyridoxine in the metabolism of the chick. 2 molecules of inhibitor were sufficient to offset the vitamin activity of 1 molecule of pyridoxine. In the course of an investigation of antimalarials, McCasland et al. (2) ...